Research

Our research activities are centered on the application of green solvents such as water, ionic liquids, and fluorous media in the development of sustainable chemical processes. Since we strongly believe that molecular level understanding of reactions is a key part of designing green and competitive technologies, we are routinely using in situ spectroscopy to establish the reaction mechanisms involved.

 Biphase Chemistry
A Green Approach to Catalyst or Reagent Recycling

Simple and efficient separation of products from a catalyst or reagent under mild conditions is crucial to the application of liquid phase chemistry in industrial processes. The use of biphase systems, in which one of the phases contains the dissolved catalyst or reagent, could allow particularly easy separation of the products. A biphase homogeneous catalyst or reagent is designed to preferentially dissolve in the catalyst or reagent phase. The required solubility can be achieved by attaching solubilizing groups to the catalyst or reagent. If the products have limited solubility in the catalyst or reagent phase, a second, product phase could form during the conversion of the reactants, which can be easily separated.

biphasecatalysis

We are currently exploring the application of water, ionic liquids and fluorous media as the catalyst or reagent phase:

  • Horváth, I. T. Fluorous Biphase Chemistry Acc. Chem. Res. 1998, 31, 641.
  • Horváth, I. T. Fluorous Phase Aqueous Phase Organometallic Catalysis – Concepts and Applications, Cornils, B.; Herrmann, W. A.; (Eds.), WILEY-VCH, Weinheim (1998) pp. 548-554.
  • Horváth, I. T. Fluorous Phase Catalysis Catalysis from A to Z, Cornils, B.; Herrmann, W. A. Schlögl, R.; Wong, C.-H. (Eds.), WILEY-VCH, Weinheim, (2000) pp. 222-223.
  • Csihony, S.; Mehdi, H.; Horváth, I. T. In Situ Infrared Spectroscopic Studies of the Friedel-Crafts Acetylation of Benzene in Ionic Liquids Using AlCl3 and FeCl3 Green Chem. 2001, 3, 307.
  • Csihony, S.; Mehdi, H.; Hommonay, Z.; Vértes, A.; Farkas, Ö.; Horváth, I. T. In Situ Spectroscopic Studies Related to the Mechanism of the Friedel-Crafts Acetylation of Benzene in Ionic Liquids Using AlCl3 and FeCl3 
    J. Chem. Soc. Dalton Transaction.
    2002, 71, 680.
  • Vlád, G.; Horváth, I. T. Improved Synthesis of 2,2′-Bipyrimidine J. Org. Chem. 2002, 67, 6550.
  • Csihony, S.; Fischmeister, C.; Bruneau, C.; Horváth, I. T.; Dixneuf, P. H. First Ring-opening Metathesis Polymerization in an Ionic Liquid. Efficient Recycling of a Catalyst Generated from a Cationic Ruthenium Allenylidene Complex New J. Chem. 2002, 26, 1667
  • de Rege, P. J. F.; Gladysz, J. A.; Horváth, I. T. Facile and Selective Carbonylation of Methane in Superacids
    Adv. Synth. & Cat. 2002, 344, 1059.
  • Csihony, S.; Bodor, A; Rohonczy, J.; Horváth, I. T. In Situ IR and NMR Spectroscopic Investigation of the Formation and Structure of Protonated Diacetylketene Tetrachloroaluminate. J. Chem. Soc. Perkin Transaction I. 2002, 2861.
  • Horváth, I. T. Zöld Kémia (Green Chemistry in Hungarian) Magyar Tudomány, 2002, 1585.
  • Rábai, J. Szlávik, Z.; Horváth, I. T. Chemistry in Fluorous Biphasic Systems Handbook of Green Chemistry & Technology, Clark, J.; Macquarrie, D. (Eds.), Blackwell, Oxford (2002) pp. 502-523.
  • Horváth, I. T. Green Chemistry and Combinatorial Approaches ICS Proceedings, Expert Group Meetings on Technologies and Processes for Sustainable Development and Pollution Reduction/Prevention, Masek, I; Miertus, S. (Eds.), Brno University of Technology (ISBN 80-214-2151-7), Brno, (2002) pp. 166-170.
  • Horváth, I. T.; Náray-Szabó, G. Sustainable/Green Chemistry in Hungary ICS Proceedings, Expert Group Meetings on Technologies and Processes for Sustainable Development and Pollution Reduction/Prevention, Masek, I; Miertus, S. (Eds.), Brno University of Technology (ISBN 80-214-2151-7), Brno, (2002) pp. 198-200.
  • Horváth, I. T. Immobilization by Other Immiscible Phases: Fluorous Phases Applied Homogeneous Catalysis with Organometallic Compounds, Cornils, B.; Herrmann, W. A. (Eds.), VCH, Weinheim (2002) pp. 634-639.
  • Gladysz, J. A..; Curran, D. P. Horváth, I. T. (Eds) Handbook of Fluorous Chemistry, Wiley-VCH, Weinheim, 2004.
  • Cornils, B.; Herrmann, W. A.; Horváth, I. T.; Leitner, W.; Mecking, S.; Olivier-Bourbigou, H.; Vogt, D. (Eds) Multiphase Homogeneous Catalysis, Wiley-VCH, Weinheim, 2005.